Increased Eosinophilic Cationic Protein in Nasal Fluid in Hospitalized Wheezy Infants with RSV Infection

Respiratory syncytial virus (RSV) is a major respiratory pathogen which causes bronchiolitis with dyspnea and wheezing in children less than 2 years old. RSV bronchiolitis in infancy severe enough to cause hospitalization might be a risk factor for allergic sensitization and bronchial asthma in futu...

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Veröffentlicht in:	Allergology international 2011, Vol.60 (4), p.467-472
Hauptverfasser:	Okamoto, Naoko, Ikeda, Masanori, Okuda, Masato, Sakamoto, Tomoko, Takasugi, Mizue, Takahashi, Nobumasa, Araki, Toru, Morishima, Tsuneo, Yasui, Kozo
Format:	Artikel
Sprache:	eng
Schlagworte:	airway inflammation Eosinophil Cationic Protein - analysis eosinophilic cationic protein eosinophils Female Hospitalization Humans Hypersensitivity - immunology Infant Infant, Newborn Male Nasal Lavage Fluid - immunology neutrophils Respiratory Sounds - etiology Respiratory Sounds - immunology respiratory syncitial virus Respiratory Syncytial Virus Infections - immunology Time Factors
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Zusammenfassung:	Respiratory syncytial virus (RSV) is a major respiratory pathogen which causes bronchiolitis with dyspnea and wheezing in children less than 2 years old. RSV bronchiolitis in infancy severe enough to cause hospitalization might be a risk factor for allergic sensitization and bronchial asthma in future. However, the pathophysiology behind this development has not been clearly characterized. To evaluate the existence of airway inflammation and characteristic of RSV bronchiolitis, we analyzed and compared the concentrations of eosinophilic cationic protein (ECP) in nasal fluid and plasma. From 69 infants (aged
ISSN:	1323-8930 1440-1592
DOI:	10.2332/allergolint.10-OA-0263