The human egomotion network

•Egomotion compatible visual and vestibular stimulation elicits responses in five core hubs: area CSv, PcM/pCi, VPS, the uvula, and a region in cytoarchitectonic areas PF/PFcm.•The region in cytoarchitectonic areas PF/PFcm represents the human correlate of multisensory macaque area 7a.•Areas VIP and hMST do not form part of the core egomotion network.•Functional role of cortico-cerebellar axis between the cingulate sulcus and the uvula during egomotion perception.•Common neurotransmitter profile for all five egomotion hubs.•Connectopic mapping revealed significant gradients exclusively within the uvula and area CSv. All volitional movement in a three-dimensional space requires multisensory integration, in particular of visual and vestibular signals. Where and how the human brain processes and integrates self-motion signals remains enigmatic. Here, we applied visual and vestibular self-motion stimulation using fast and precise whole-brain neuroimaging to delineate and characterize the entire cortical and subcortical egomotion network in a substantial cohort (n=131). Our results identify a core egomotion network consisting of areas in the cingulate sulcus (CSv, PcM/pCi), the cerebellum (uvula), and the temporo-parietal cortex including area VPS and an unnamed region in the supramarginal gyrus. Based on its cerebral connectivity pattern and anatomical localization, we propose that this region represents the human homologue of macaque area 7a. Whole-brain connectivity and gradient analyses imply an essential role of the connections between the cingulate sulcus and the cerebellar uvula in egomotion perception. This could be via feedback loops involved updating visuo-spatial and vestibular information. The unique functional connectivity patterns of PcM/pCi hint at central role in multisensory integration essential for the perception of self-referential spatial awareness. All cortical egomotion hubs showed modular functional connectivity with other visual, vestibular, somatosensory and higher order motor areas, underlining their mutual function in general sensorimotor integration. [Display omitted]