Successful Treatment of Balamuthia mandrillaris Granulomatous Amebic Encephalitis with Nitroxoline

Successful Treatment of Balamuthia mandrillaris Granulomatous Amebic Encephalitis with Nitroxoline

A patient in California, USA, with rare and usually fatal Balamuthia mandrillaris granulomatous amebic encephalitis survived after receiving treatment with a regimen that included the repurposed drug nitroxoline. Nitroxoline, which is a quinolone typically used to treat urinary tract infections, was...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Emerging infectious diseases 2023-01, Vol.29 (1), p.197-201
Hauptverfasser: Spottiswoode, Natasha, Pet, Douglas, Kim, Annie, Gruenberg, Katherine, Shah, Maulik, Ramachandran, Amrutha, Laurie, Matthew T, Zia, Maham, Fouassier, Camille, Boutros, Christine L, Lu, Rufei, Zhang, Yueyuan, Servellita, Venice, Bollen, Andrew, Chiu, Charles Y, Wilson, Michael R, Valdivia, Liza, DeRisi, Joseph L
Format: Artikel
Sprache:eng
Schlagworte:
Abscesses
ameba
ameba drug effects
Amebiasis
Amebiasis - drug therapy
Aphasia
Balamuthia mandrillaris
Biopsy
Brain
Brain research
California
Care and treatment
Case studies
Disease control
Dispatch
Dosage and administration
Drug dosages
Drug therapy
Edema
Encephalitis
Fluconazole
Flucytosine
Granuloma
granulomatous amebic encephalitis
Granulomatous Amebic Encephalitis with Nitroxoline
Health aspects
Humans
Infectious diseases
Infectious Encephalitis
Kidneys
Levetiracetam
Magnetic resonance imaging
Medical prognosis
Mortality
nitroxoline
Patients
Pentamidine isethionate
Quinolones
Successful Treatment of
Sulfadiazine
Urinary tract diseases
Urinary tract infections
Urogenital system
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A patient in California, USA, with rare and usually fatal Balamuthia mandrillaris granulomatous amebic encephalitis survived after receiving treatment with a regimen that included the repurposed drug nitroxoline. Nitroxoline, which is a quinolone typically used to treat urinary tract infections, was identified in a screen for drugs with amebicidal activity against Balamuthia.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2901.221531