Myonuclear content regulates cell size with similar scaling properties in mice and humans

Muscle fibers are the largest cells in the body, and one of its few syncytia. Individual cell sizes are variable and adaptable, but what governs cell size has been unclear. We find that muscle fibers are DNA scarce compared to other cells, and that the nuclear number ( N ) adheres to the relationshi...

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Veröffentlicht in:	Nature communications 2020-12, Vol.11 (1), p.6288-14, Article 6288
Hauptverfasser:	Hansson, Kenth-Arne, Eftestøl, Einar, Bruusgaard, Jo C., Juvkam, Inga, Cramer, Alyssa W., Malthe-Sørenssen, Anders, Millay, Douglas P., Gundersen, Kristian
Format:	Artikel
Sprache:	eng
Schlagworte:	14/19 14/34 631/136 692/698/1671/1668/1973 Adult Animals Atrophy Biopsy Cell Nucleus - chemistry Cell Size Cell surface Cytoplasm Denervation Deoxyribonucleic acid Developmental stages DNA DNA - analysis Female Fibers Healthy Volunteers Humanities and Social Sciences Humans Intravital Microscopy Male Mice Microscopy, Confocal multidisciplinary Muscle Fibers, Skeletal - chemistry Muscle Fibers, Skeletal - cytology Muscle, Skeletal - cytology Muscle, Skeletal - growth & development Muscle, Skeletal - pathology Muscles Nuclei Nuclei (cytology) Scaling Scaling laws Science Science (multidisciplinary) Single-Cell Analysis Syncytia Young Adult
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Zusammenfassung:	Muscle fibers are the largest cells in the body, and one of its few syncytia. Individual cell sizes are variable and adaptable, but what governs cell size has been unclear. We find that muscle fibers are DNA scarce compared to other cells, and that the nuclear number ( N ) adheres to the relationship N = aV b where V is the cytoplasmic volume. N invariably scales sublinearly to V ( b
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-020-20057-8