High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern

SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies; therefore, treatment alternatives are needed. We tested therapeutic equine polyclonal antibodies (pAbs) that are being assessed in clinical trials in Costa Rica against five globally...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Frontiers in medicine 2021-09, Vol.8, p.735853-735853
Hauptverfasser: Moreira-Soto, Andres, Arguedas, Mauricio, Brenes, Hebleen, Buján, Willem, Corrales-Aguilar, Eugenia, Díaz, Cecilia, Echeverri, Ann, Flores-Díaz, Marietta, Gómez, Aarón, Hernández, Andrés, Herrera, María, León, Guillermo, Macaya, Román, Kühne, Arne, Molina-Mora, José Arturo, Mora, Javier, Sanabria, Alfredo, Sánchez, Andrés, Sánchez, Laura, Segura, Álvaro, Segura, Eduardo, Solano, Daniela, Soto, Claudio, Stynoski, Jennifer L., Vargas, Mariángela, Villalta, Mauren, Reusken, Chantal B. E. M., Drosten, Christian, Gutiérrez, José María, Alape-Girón, Alberto, Drexler, Jan Felix
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies; therefore, treatment alternatives are needed. We tested therapeutic equine polyclonal antibodies (pAbs) that are being assessed in clinical trials in Costa Rica against five globally circulating variants of concern: alpha, beta, epsilon, gamma and delta, using plaque reduction neutralization assays. We show that equine pAbs efficiently neutralize the variants of concern, with inhibitory concentrations in the range of 0.146–1.078 μg/mL, which correspond to extremely low concentrations when compared to pAbs doses used in clinical trials. Equine pAbs are an effective, broad coverage, low-cost and a scalable COVID-19 treatment.
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2021.735853