Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer

Immune checkpoint blockade (ICB) therapy has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment, but

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Bibliographische Detailangaben
Veröffentlicht in:	Nature communications 2021-04, Vol.12 (1), p.2383-2383, Article 2383
Hauptverfasser:	Wang, Zhiyong, Goto, Yusuke, Allevato, Michael M., Wu, Victoria H., Saddawi-Konefka, Robert, Gilardi, Mara, Alvarado, Diego, Yung, Bryan S., O’Farrell, Aoife, Molinolo, Alfredo A., Duvvuri, Umamaheswar, Grandis, Jennifer R., Califano, Joseph A., Cohen, Ezra E. W., Gutkind, J. Silvio
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 13 13/1 13/95 631/67/1665 631/80/86 AKT protein Animals Antibodies Anticancer properties Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell Proliferation - genetics Circuits Class I Phosphatidylinositol 3-Kinases - genetics Class I Phosphatidylinositol 3-Kinases - metabolism Female Genetic screening Head & neck cancer Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - genetics Head and Neck Neoplasms - immunology Head and Neck Neoplasms - pathology Human papillomavirus Humanities and Social Sciences Humans Immune checkpoint Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use Immunotherapy Immunotherapy - methods Kinases Lymphocytes Medical prognosis Mice Mortality multidisciplinary Mutation Otolaryngology PD-1 protein Phosphorylation Precision Medicine - methods Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - metabolism Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Receptor, ErbB-3 - antagonists & inhibitors Receptor, ErbB-3 - metabolism Remission Science Science (multidisciplinary) Signal Transduction - drug effects Signal Transduction - genetics Signaling siRNA Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - drug therapy Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - immunology Squamous Cell Carcinoma of Head and Neck - pathology Surgery TOR protein TOR Serine-Threonine Kinases - metabolism Tumor microenvironment Tumor Microenvironment - drug effects Tumor Microenvironment - immunology Tyrosine Xenograft Model Antitumor Assays
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Beschreibung
Zusammenfassung:	Immune checkpoint blockade (ICB) therapy has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment, but
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-021-22619-w