Parathormone levels add prognostic ability to N‐terminal pro‐brain natriuretic peptide in stable coronary patients

Aims There are controversial data on the ability of the components of mineral metabolism (vitamin D, phosphate, parathormone [PTH], fibroblast growth factor‐23 [FGF23], and klotho) to predict cardiovascular events. In addition, it is unknown whether they add any prognostic value to other well‐known...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:ESC Heart Failure 2021-08, Vol.8 (4), p.2713-2722
Hauptverfasser: Gutiérrez‐Landaluce, Carlos, Aceña, Álvaro, Pello, Ana, Martínez‐Milla, Juan, González‐Lorenzo, Óscar, Tarín, Nieves, Cristóbal, Carmen, Blanco‐Colio, Luis M., Martín‐Ventura, José Luis, Huelmos, Ana, López‐Castillo, Marta, Alonso, Joaquín, López Bescós, Lorenzo, Alonso‐Pulpón, Luis, González‐Parra, Emilio, Egido, Jesús, Mahíllo‐Fernández, Ignacio, Lorenzo, Óscar, González‐Casaus, María Luisa, Tuñón, José
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Aims There are controversial data on the ability of the components of mineral metabolism (vitamin D, phosphate, parathormone [PTH], fibroblast growth factor‐23 [FGF23], and klotho) to predict cardiovascular events. In addition, it is unknown whether they add any prognostic value to other well‐known biomarkers. Methods and results In 969 stable coronary patients, we determined plasma levels of all the aforementioned components of mineral metabolism with a complete set of clinical and biochemical variables, including N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), high‐sensitivity troponin I (hs‐TnI), and high‐sensitivity C‐reactive protein. Secondary outcomes were ischaemic events (any acute coronary syndrome, stroke, or transient ischaemic attack) and heart failure or death. The primary outcome was a composite of the secondary outcomes. Median follow‐up was 5.39 years. Age was 60 (52–72) years. Median glomerular filtration rate was 80.4 (65.3–93.1) mL/min/1.73 m2. One‐hundred and eighty‐five patients developed the primary outcome. FGF23, PTH, hs‐TnI, and NT‐proBNP were directly related with the primary outcome on univariate Cox analysis, while Klotho and calcidiol were inversely related. On multivariate analysis, only PTH (HR 1.058 [CI 1.021–1.097]; P = 0.002) and NT‐proBNP (HR 1.020 [CI 1.012–1.028]; P 
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.13331