Molecular Pathology

Notably, immunofluorescence techniques invented by Albert Coons in 1961permitted detection of proteins in cells and tissues, [2] and in 1975, Edwin Southern invented the Southern blot to hybridize probes to specific DNA sequences and used the technique to identify a particular genetic polymorphism co-occurring with X-linked retinitis pigmentosa [3]. Recent advances in molecular pathology, especially the development of profiling systems with higher resolution (including spatial resolution), higher plex, and ability to characterize multiple analytes from a single sample, are continuing to push the field forward. Parallel advances in statistical methods and artificial intelligence/machine learning approaches for data analysis will also drive greater biological insights and ultimately advances in patient care.