MicroRNA‐binding site polymorphisms and risk of colorectal cancer: A systematic review and meta‐analysis

Genetic variations in miRNAs binding site might participate in cancer risk. This study aimed to systematically review the association between miRNA‐binding site polymorphisms and colorectal cancer (CRC). Electronic literature search was carried out on PubMed, Web of Science (WOS), Scopus, and Embase...

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Veröffentlicht in:	Cancer medicine (Malden, MA) MA), 2019-12, Vol.8 (17), p.7477-7499
Hauptverfasser:	Gholami, Morteza, Larijani, Bagher, Sharifi, Farshad, Hasani‐Ranjbar, Shirin, Taslimi, Reza, Bastami, Milad, Atlasi, Rasha, Amoli, Mahsa M.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Alleles Asia, Eastern - epidemiology Asian People - genetics Binding sites Binding Sites - genetics Biomarkers Cancer Cancer Prevention Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - epidemiology Colorectal Neoplasms - genetics Czech Republic - epidemiology Ethnicity Gene Expression Regulation, Neoplastic Genetic analysis Genetic diversity Genetic Predisposition to Disease Heterozygotes Humans Medical prognosis Meta-analysis MicroRNAs MicroRNAs - metabolism Middle East - epidemiology miRNA Observational Studies as Topic Original Research Polymorphism Polymorphism, Single Nucleotide Population Population genetics Risk Factors Single-nucleotide polymorphism Studies Systematic review Tumors
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Zusammenfassung:	Genetic variations in miRNAs binding site might participate in cancer risk. This study aimed to systematically review the association between miRNA‐binding site polymorphisms and colorectal cancer (CRC). Electronic literature search was carried out on PubMed, Web of Science (WOS), Scopus, and Embase. All types of observational studies till 30 November 2018 were included. Overall 85 studies (21 SNPs) from two systematic searches were included analysis. The results showed that in the Middle East population, the minor allele of rs731236 was associated with decreased risk of CRC (heterozygote model: 0.76 [0.61‐0.95]). The minor allele of rs3025039 was related to increased risk of CRC in East Asian population (allelic model: 1.25 [1.01‐1.54]). Results for rs3212986 were significant in overall and subgroup analysis (P
ISSN:	2045-7634 2045-7634
DOI:	10.1002/cam4.2600