Role of platelet biomarkers in inflammatory response

Beyond hemostasis, thrombosis and wound healing, it is becoming increasingly clear that platelets play an integral role in inflammatory response and immune regulation. Platelets recognize pathogenic microorganisms and secrete various immunoregulatory cytokines and chemokines, thus facilitating a var...

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Veröffentlicht in:	Biomarker research 2020-08, Vol.8 (1), p.1-28, Article 28
Hauptverfasser:	Chen, Yufei, Zhong, Haoxuan, Zhao, Yikai, Luo, Xinping, Gao, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation-related biomarkers Atherosclerosis Bacteria Biological markers Biomarkers Blood platelets Canakinumab Chemokines Cytokines Cytotoxicity Dendritic cells Hemostasis Immune regulation Immunoregulation Infections Inflammation Inflammatory response Ligands Lymphocytes Neutrophils Pathogens Plasma Platelet Platelets Proteins Review RNA Sepsis Thrombosis Tofacitinib Viruses Wound healing
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Beschreibung
Zusammenfassung:	Beyond hemostasis, thrombosis and wound healing, it is becoming increasingly clear that platelets play an integral role in inflammatory response and immune regulation. Platelets recognize pathogenic microorganisms and secrete various immunoregulatory cytokines and chemokines, thus facilitating a variety of immune effects and regulatory functions. In this review, we discuss recent advances in signaling of platelet activation-related biomarkers in inflammatory settings and application prospects to apply for disease diagnosis and treatment.
ISSN:	2050-7771 2050-7771
DOI:	10.1186/s40364-020-00207-2