Harnessing Antibody-Mimetic Selectivity for Activation-State-Specific Targeted Degradation of Endogenous K‑Ras

Harnessing Antibody-Mimetic Selectivity for Activation-State-Specific Targeted Degradation of Endogenous K‑Ras

Inducible anti-Ras biodegraders as biological tools to interrogate nucleotide-loaded states across a panel of K-Ras mutants are developed.

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Veröffentlicht in:ACS central science 2021-02, Vol.7 (2), p.222-224
1. Verfasser: Ferguson, Fleur M
Format: Artikel
Sprache:eng
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Zusammenfassung:Inducible anti-Ras biodegraders as biological tools to interrogate nucleotide-loaded states across a panel of K-Ras mutants are developed.
ISSN:2374-7943
2374-7951
DOI:10.1021/acscentsci.1c00084