Formulation and In Vitro Characterization of Mouth Dissolving Film of Clopidogrel Hydrogen Sulphate

The purpose of the present investigation was to formulate a mouth-dispersing film of a Clopidogrel Hydrogen Sulphate dosage form for a rapid onset of action, which is very easy for administration, without the issue of swallowing and using water. The Mouth Dissolving Film of Clopidogrel Hydrogen Sulphate was prepared through the Solvent Casting Method and its in vitro characterization was evaluated. The folding endurance is 173.6 ± 0.22, and the drug content is 96.33 ± 1.15. The drug release rate of the optimized formula A4 is 96.00% in 5 min, and it was concluded according to this result that the film prepared using an HPMC E5 polymer forms superior film that offers rapid drug release.