Cladieunicellins M-Q, new eunicellins from Cladiella sp

Five new 7α-hydroxyeunicellin-based diterpenoids, designated as cladieunicellins M-Q (1-5), were isolated from a Formosan octocoral Cladiella sp. The structures of 1-5 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxic...

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Veröffentlicht in:	Marine drugs 2014-04, Vol.12 (4), p.2144-2155
Hauptverfasser:	Chen, Tsung-Hung, Chen, Wu-Fu, Wen, Zhi-Hong, Lu, Mei-Chin, Wang, Wei-Hsien, Li, Jan-Jung, Wu, Yang-Chang, Sung, Ping-Jyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthozoa - metabolism Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Cell Line, Tumor Cladiella cladieunicellin Communication cytotoxicity Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology eunicellin HL-60 Cells Humans Inhibitory Concentration 50 Leukemia - drug therapy Leukemia - pathology Marine Spectrum Analysis Structure-Activity Relationship
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Zusammenfassung:	Five new 7α-hydroxyeunicellin-based diterpenoids, designated as cladieunicellins M-Q (1-5), were isolated from a Formosan octocoral Cladiella sp. The structures of 1-5 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1-5 against the human leukemia Molt 4 and HL 60 is also described. Among them, compounds 1, 3 and 5 exhibited moderate cytotoxicity toward Molt 4 cells with IC₅₀ values 16.43, 14.17 and 15.55 μM, respectively. Preliminary SAR (structure activity relationship) information was obtained from these compounds and their analogues.
ISSN:	1660-3397 1660-3397
DOI:	10.3390/md12042144