Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes

In this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl- -phenyl-1H-pyrazole-3-carboxamide ( ) and 1,5-dimethyl- -propyl-1H-pyrazole-3-carboxamide ( ), with the aim to investigate bio-inorganic properties. Their crystal structures revealed a mono...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2024-03, Vol.29 (5), p.1186
Hauptverfasser:	El Mahdaoui, Amal, Radi, Smaail, Draoui, Youssef, El Massaoudi, Mohamed, Ouahhoud, Sabir, Asehraou, Abdeslam, Bentouhami, Nour Eddine, Saalaoui, Ennouamane, Benabbes, Redouane, Robeyns, Koen, Garcia, Yann
Format:	Artikel
Sprache:	eng
Schlagworte:	amide antibacterial and antifungal activity Antibiotics Antifungal agents Bacteria Chloride coordination complexes Crystallography Drug resistance E coli genotoxicity Ligands Listeria Metals pyrazole Single crystals Spectrum analysis
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Beschreibung
Zusammenfassung:	In this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl- -phenyl-1H-pyrazole-3-carboxamide ( ) and 1,5-dimethyl- -propyl-1H-pyrazole-3-carboxamide ( ), with the aim to investigate bio-inorganic properties. Their crystal structures revealed a mononuclear complex [Ni( ) ](ClO ) ( ) and a dinuclear complex [Cd ( ) ]Cl ( ). Very competitive antifungal and anti-Fusarium activities were found compared to the reference standard cycloheximide. Additionally, and present very weak genotoxicity in contrast to the observed increase in genotoxicity for the coordination complexes and .
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules29051186