Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance

In an investigation of six anti-SARS-CoV-2 antibody kits with different target antigen and methodology, each kit showed comparable performance. As false-positive reactions occurred independently with different kits, specificity increased to 100% when pairs of kits were used. With three-kit combinati...

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Veröffentlicht in:	Journal of microbiology, immunology and infection immunology and infection, 2021-10, Vol.54 (5), p.983-986
Hauptverfasser:	Ko, Jae-Hoon, Joo, Eun-Jeong, Baek, Jin Yang, Huh, Kyungmin, Cho, Sun Young, Kang, Cheol-In, Chung, Doo Ryeon, Kim, Yae-Jean, Kang, Eun-Suk, Peck, Kyong Ran
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibody Combination COVID-19 SARS-CoV-2 Short Communication
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	In an investigation of six anti-SARS-CoV-2 antibody kits with different target antigen and methodology, each kit showed comparable performance. As false-positive reactions occurred independently with different kits, specificity increased to 100% when pairs of kits were used. With three-kit combination, both sensitivity (99.1%) and specificity (100%) increased.
ISSN:	1684-1182 1995-9133
DOI:	10.1016/j.jmii.2021.03.008