Population pharmacokinetic modeling to facilitate dose selection of tapentadol in the pediatric population

Population pharmacokinetic modeling to facilitate dose selection of tapentadol in the pediatric population

The main aim of this analysis was to characterize the pharmacokinetics (PK) of the strong analgesic tapentadol in 2-year-old to

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Bibliographische Detailangaben
Veröffentlicht in:Journal of pain research 2019-10, Vol.12, p.2835-2850
Hauptverfasser: Watson, Estelle, Khandelwal, Akash, Freijer, Jan, van den Anker, John, Lefeber, Claudia, Eerdekens, Mariëlle
Format: Artikel
Sprache:eng
Schlagworte:
Acute pain
Age groups
Analgesics
Child health
Clinical trials
dosing
Drug dosages
Enzymes
Ethics
Metabolism
Metabolites
Narcotics
nonlinear mixed effects modeling
Operating systems (Software)
Oral drugs
Original Research
Pain
Pain management
Patients
pediatric
Pediatric pain
Pediatrics
Pharmaceutical industry
Pharmacokinetics
Review boards
Tapentadol
Youth
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Beschreibung
Zusammenfassung:The main aim of this analysis was to characterize the pharmacokinetics (PK) of the strong analgesic tapentadol in 2-year-old to
ISSN:1178-7090
1178-7090
DOI:10.2147/JPR.S208454