The French multicentric molecular analysis platforms and personalized medicine trials MOST, MOST Plus and MEGAMOST

In this manuscript we describe the academic French multicentric molecular analysis platforms including PROFILER, promoted by Centre Léon Berard, and the multicentric personalized medicine trials MOST, MOST Plus and MEGAMOST. MOST, MOST Plus and MEGAMOST comprise 14 cohorts with different targeted agents and immunotherapies. PROFILER has recruited 5,991 patients in 10 years, MOST and MOST Plus 875 patients since 2014 and MEGAMOST 172 patients since 2020, and are still ongoing. We provide a description of the local, national and international implications of these initiatives, and we review the results of the sorafenib and olaparib cohorts.