The associations of glycosylated hemoglobin with grey matter volume and depression: Investigating mediating role of grey matter volume

The associations of glycosylated hemoglobin with grey matter volume and depression: Investigating mediating role of grey matter volume

Depression has caused enormous health burden to human worldwide. Glycemia has been found as one important risk factor of depression. However, the biological mechanism underlying this relationship remained largely unknown. This analysis was derived from a cohort of 33,151 participants in the UK Bioba...

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Veröffentlicht in:Global transitions 2023, Vol.5, p.107-116
Hauptverfasser: Zheng, Dashan, Cai, Miao, Qian, Zhengmin (Min), Wang, Chongjian, Zhang, Shiyu, Zhang, Zilong, Wang, Xiaojie, Vaughn, Michael G., Bingheim, Elizabeth, Lin, Hualiang
Format: Artikel
Sprache:eng
Schlagworte:
Depression
Glycosylated hemoglobin
Grey matter volume
Mediation analysis
UK biobank
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Zusammenfassung:Depression has caused enormous health burden to human worldwide. Glycemia has been found as one important risk factor of depression. However, the biological mechanism underlying this relationship remained largely unknown. This analysis was derived from a cohort of 33,151 participants in the UK Biobank who provided brain magnetic resonance imaging data from 2014 to 2020. Participants were classified into diabetic, prediabetic and non-diabetic groups, as well as groups aged ≥60 years and
ISSN:2589-7918
2589-7918
DOI:10.1016/j.glt.2023.06.004