Dose-Response Modeling of Aflatoxin B1-Induced Apoptosis Rate in Rat Hepatocytes

This study aimed to construct a dose-response model of aflatoxin B1 (AFB1)-induced apoptosis rate in rat hepatocytes by using quantitative data. The coefficients of determination (R2) and further mathematical tests showed that the Gamma model (R2 = 0.996 4, Akaike information criterion = 37.40, and Bayesian information criterion = 17.19) was superior to other models. Hence, the Gamma model was recommended as the optimal dose-response model for apoptosis rate in rat hepatocytes after acute exposure to AFB1 for hazard characterization in the framework of AFB1 risk assessment.