Hondroplastic Efficiency of Calcified Bone Matrix Produced by Original Technology

The purpose of our research was to study the chondroplastic efficiency of the bone matrix obtained by the original technology, while restoring the defect of cartilage of the knee joint. Methods: In 40 adult Wistar male rats, marginal defects were modeled on the surface of the distal end of the femur. The animals of the experimental group were implanted with bone matrix into the damage zone. The material was examined by light microscopy, transmission and scanning electron microscopy, and X-ray electron probe microanalysis. Results: It was established that bone matrix did not cause immune rejection reaction and has prolonged activated reparative chondrogenesis. In the area of articular cartilage damage, a regenerate was formed, acquiring cellular and histochemical specificity of the hyaline cartilaginous tissue. The properties of the chondroinductor to the bone matrix were ensured by localized growth factors and bone morphogenetic proteins released during osteoclastic resorption. Conclusion: The use of bone matrix as a stimulant of chondrogenesis is theoretically justified and has a good prospect in the treatment of articular cartilage damage and diseases.