Hepatitis B infection is causally associated with extrahepatic cancers: A Mendelian randomization study

Evidence from observational studies suggests that chronic hepatitis B virus (HBV) infection is associated with extrahepatic cancers. However, the causal association between chronic HBV infection and extrahepatic cancers remains to be determined. We performed two-sample Mendelian randomization (MR) t...

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Veröffentlicht in:	EBioMedicine 2022-05, Vol.79, p.104003-104003, Article 104003
Hauptverfasser:	Kamiza, Abram Bunya, Fatumo, Segun, Singini, Mwiza Gideon, Yeh, Chih-Ching, Chikowore, Tinashe
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - genetics Female Genetics Genome-Wide Association Study - methods HBV Hepatitis B - complications Hepatitis B - genetics Hepatitis B, Chronic - complications Hepatitis B, Chronic - genetics Humans Liver Neoplasms - etiology Liver Neoplasms - genetics Mendelian randomization Mendelian Randomization Analysis - methods Polymorphism, Single Nucleotide SNPs
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Zusammenfassung:	Evidence from observational studies suggests that chronic hepatitis B virus (HBV) infection is associated with extrahepatic cancers. However, the causal association between chronic HBV infection and extrahepatic cancers remains to be determined. We performed two-sample Mendelian randomization (MR) to investigate whether chronic HBV infection is causally associated with extrahepatic cancers. We identified four independent genetic variants strongly associated (P-value
ISSN:	2352-3964 2352-3964
DOI:	10.1016/j.ebiom.2022.104003