Prediction of childhood brain outcomes in infants born preterm using neonatal MRI and concurrent clinical biomarkers (PREBO-6): study protocol for a prospective cohort study

IntroductionInfants born very preterm are at risk of adverse neurodevelopmental outcomes, including cognitive deficits, motor impairments and cerebral palsy. Earlier identification enables targeted early interventions to be implemented with the aim of improving outcomes.Methods and analysisProtocol...

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Veröffentlicht in:	BMJ open 2020-05, Vol.10 (5), p.e036480-e036480
Hauptverfasser:	George, Joanne M, Pagnozzi, Alex M, Bora, Samudragupta, Boyd, Roslyn N, Colditz, Paul B, Rose, Stephen E, Ware, Robert S, Pannek, Kerstin, Bursle, Jane E, Fripp, Jurgen, Barlow, Karen, Iyer, Kartik, Leishman, Shaneen J, Jendra, Rebecca L
Format:	Artikel
Sprache:	eng
Schlagworte:	Academic achievement Academic Success Age Australia - epidemiology Biomarkers Biomarkers - metabolism Brain - diagnostic imaging Brain - physiopathology Brain research Cerebral palsy Cerebral Palsy - diagnosis Cerebral Palsy - epidemiology Cerebral Palsy - physiopathology Childhood Cognition & reasoning Cognitive Dysfunction - diagnosis Cognitive Dysfunction - epidemiology Cognitive Dysfunction - physiopathology Cohort analysis Early Medical Intervention - methods Electroencephalography Electroencephalography - methods Female Follow-Up Studies Gestational Age Humans Hypotheses Infant, Newborn Language Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical imaging Mental health Mental Health - statistics & numerical data Motor Neuron Disease - diagnosis Motor Neuron Disease - epidemiology Motor Neuron Disease - physiopathology Neurodevelopmental Disorders - complications Neurodevelopmental Disorders - diagnosis Neurodevelopmental Disorders - epidemiology Newborn babies Paediatrics Pediatrics Premature birth Premature Birth - epidemiology Prospective Studies Quality of Life Well being
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Zusammenfassung:	IntroductionInfants born very preterm are at risk of adverse neurodevelopmental outcomes, including cognitive deficits, motor impairments and cerebral palsy. Earlier identification enables targeted early interventions to be implemented with the aim of improving outcomes.Methods and analysisProtocol for 6-year follow-up of two cohorts of infants born
ISSN:	2044-6055 2044-6055
DOI:	10.1136/bmjopen-2019-036480