Effect of the formulation parameters on the encapsulation efficiency and release behavior of p-aminobenzoic acid-loaded ethylcellulose microspheres
In the current study, p-aminobenzoic acid-loaded ethylcellulose microspheres were prepared under various conditions by solvent evaporation method (o/w). This preparation was carried out with different p-aminobenzoic acid:ethylcellulose (PABA:EC) ratios, stirring speed, surfactant nature and concentr...
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Veröffentlicht in: | Journal of the Serbian Chemical Society 2016, Vol.81 (10), p.1183-1198 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | In the current study, p-aminobenzoic acid-loaded ethylcellulose microspheres
were prepared under various conditions by solvent evaporation method (o/w).
This preparation was carried out with different p-aminobenzoic
acid:ethylcellulose (PABA:EC) ratios, stirring speed, surfactant nature and
concentration in order to investigate their effect on encapsulation
efficiency and drug release kinetics. Scanning Electron Microscopy (SEM)
studies showed spherical microspheres with a porous surface and different
structures. The mean diameter of Sauter (d32) of these microparticles is in
the range from 47 to 165 ?m with PVA and from 793 to 870 ?m with Tween 80 by
adjusting process parameters. However, the encapsulation efficiency varied
from 37.52 to 79.05 % suitable for the adjustment of a p-aminobenzoic acid
with pro-longed release. Microspheres were characterized by FTIR, DSC and
XRD. The release of cation of p-aminobenzoic acid was performed in simulated
gastric medium at pH 1.2 and 37?0.5?C by UV-VIS analysis to estimate its
content. The release data were best fitted to Higuchi model with high
correlation coefficient (r?) and the obtained values of n from
Korsmeyer-Peppas showed that the drug release follows the Fickian diffusion
mechanism.
nema |
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ISSN: | 0352-5139 1820-7421 |
DOI: | 10.2298/JSC160308068M |