Correlation between standardized uptake value of 18F-FDG PET/CT and conductivity with pathologic prognostic factors in breast cancer

We investigated the correlation between standardized uptake value (SUV) of 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) and conductivity parameters in breast cancer and explored the feasibility of conductivity as an imaging biomarker. Both SUV and conduct...

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Veröffentlicht in:Scientific reports 2023-06, Vol.13 (1), p.9844-9844, Article 9844
Hauptverfasser: Shin, Dong-Joo, Choi, Hongyoon, Oh, Dong Kyu, Sung, Hyun Pil, Kim, Jun-Hyeong, Kim, Dong-Hyun, Kim, Soo-Yeon
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Sprache:eng
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Zusammenfassung:We investigated the correlation between standardized uptake value (SUV) of 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) and conductivity parameters in breast cancer and explored the feasibility of conductivity as an imaging biomarker. Both SUV and conductivity have the potential to reflect the tumors’ heterogeneous characteristics, but their correlations have not been investigated until now. Forty four women diagnosed with breast cancer who underwent breast MRI and 18 F-FDG PET/CT at the time of diagnosis were included. Among them, 17 women received neoadjuvant chemotherapy followed by surgery and 27 women underwent upfront surgery. For conductivity parameters, maximum and mean values of the tumor region-of-interests were examined. For SUV parameters, SUVmax, SUVmean, and SUVpeak of the tumor region-of-interests were examined. Correlations between conductivity and SUV were evaluated, and among them, the highest correlation was observed between mean conductivity and SUVpeak (Spearman’s correlation coefficient = 0.381). In a subgroup analysis for 27 women with upfront surgery, tumors with lymphovascular invasion (LVI) showed higher mean conductivity than those without LVI (median: 0.49 S/m vs 0.06 S/m, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-36958-9