Left ventricular functional recovery of infarcted and remote myocardium after ST-segment elevation myocardial infarction (METOCARD-CNIC randomized clinical trial substudy)

We aimed to evaluate the effect of early intravenous metoprolol treatment, microvascular obstruction (MVO), intramyocardial hemorrhage (IMH) and adverse left ventricular (LV) remodeling on the evolution of infarct and remote zone circumferential strain after acute anterior ST-segment elevation myoca...

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Veröffentlicht in:	Journal of cardiovascular magnetic resonance 2020-06, Vol.22 (1), p.44-12, Article 44
Hauptverfasser:	Podlesnikar, Tomaž, Pizarro, Gonzalo, Fernández-Jiménez, Rodrigo, Montero-Cabezas, Jose M, Greif, Nina, Sánchez-González, Javier, Bucciarelli-Ducci, Chiara, Marsan, Nina Ajmone, Fras, Zlatko, Bax, Jeroen J, Fuster, Valentin, Ibáñez, Borja, Delgado, Victoria
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Adrenergic beta-1 Receptor Antagonists - administration & dosage Adrenergic beta-1 Receptor Antagonists - adverse effects Aged Anterior Wall Myocardial Infarction - diagnostic imaging Anterior Wall Myocardial Infarction - pathology Anterior Wall Myocardial Infarction - physiopathology Anterior Wall Myocardial Infarction - therapy Automation Balloon angioplasty Circumferences Clinical trials Complications Coronary vessels Demographics Edema Evaluation Feature-tracking cardiovascular magnetic resonance Female Heart Heart attack Heart attacks Hemorrhage Humans Intramyocardial hemorrhage Intravenous administration Intravenous metoprolol Left ventricular remodeling Magnetic resonance Magnetic Resonance Imaging, Cine Male Metoprolol Metoprolol - administration & dosage Metoprolol - adverse effects Microvascular obstruction Microvasculature Middle Aged Myocardial infarction Myocardium Myocardium - pathology Patients Percutaneous Coronary Intervention - adverse effects Recovery of Function Software ST Elevation Myocardial Infarction - diagnostic imaging ST Elevation Myocardial Infarction - pathology ST Elevation Myocardial Infarction - physiopathology ST Elevation Myocardial Infarction - therapy ST-segment elevation myocardial infarction Time Factors Tracking Treatment Outcome Veins & arteries Ventricle Ventricular Function, Left - drug effects Ventricular Remodeling - drug effects
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Zusammenfassung:	We aimed to evaluate the effect of early intravenous metoprolol treatment, microvascular obstruction (MVO), intramyocardial hemorrhage (IMH) and adverse left ventricular (LV) remodeling on the evolution of infarct and remote zone circumferential strain after acute anterior ST-segment elevation myocardial infarction (STEMI) with feature-tracking cardiovascular magnetic resonance (CMR). A total of 191 patients with acute anterior STEMI enrolled in the METOCARD-CNIC randomized clinical trial were evaluated. LV infarct zone and remote zone circumferential strain were measured with feature-tracking CMR at 1 week and 6 months after STEMI. In the overall population, the infarct zone circumferential strain significantly improved from 1 week to 6 months after STEMI (- 8.6 ± 9.0% to - 14.5 ± 8.0%; P
ISSN:	1097-6647 1532-429X
DOI:	10.1186/s12968-020-00638-8