Evaluation of Antidiabetic Effect of Ethanolic Leaves Extract of Becium grandiflorum Lam. (Lamiaceae) in Streptozotocin-Induced Diabetic Mice

has been used traditionally for treatment of different ailments including diabetes mellitus although it lacks scientific evidence. Thus, the present study was aimed at evaluating the antidiabetic effect of in streptozotocin (STZ)-induced diabetic mice. The antidiabetic activity of hydro-ethanolic (...

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Veröffentlicht in:Diabetes, metabolic syndrome and obesity metabolic syndrome and obesity, 2020-01, Vol.13, p.1481-1489
Hauptverfasser: Gebremeskel, Leake, Beshir Tuem, Kald, Teklu, Tewolde
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Sprache:eng
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Zusammenfassung:has been used traditionally for treatment of different ailments including diabetes mellitus although it lacks scientific evidence. Thus, the present study was aimed at evaluating the antidiabetic effect of in streptozotocin (STZ)-induced diabetic mice. The antidiabetic activity of hydro-ethanolic (30:70) leaf extract of was evaluated in STZ (45 mg/kg)-induced diabetic and normal mice. Antihyperglycemic, hypoglycemic, oral glucose tolerance and body weight change effects of the extract were assessed after administering three doses of the extract (200, 400 and 600 mg/kg), glibenclamide 5 mg/kg (reference drug) and 2% Tween 80 (vehicle). One-way analysis of variance and Tukey's post hoc test were used for data analysis. All doses of the extract (200 mg/kg (
ISSN:1178-7007
1178-7007
DOI:10.2147/DMSO.S246996