Synthesis and in vitro cytotoxic activity of compounds with pro-apoptotic potential

In our search for new anticancer therapies, some compounds synthesized in our lab were selected and their potential cytotoxic activity was evaluated in vitro against two cancer cells lines including a solid tumor (UACC-62, melanoma) and a human lymphoma (JURKAT). Compounds showing cytotoxic activity...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2009-12, Vol.15 (1), p.12-26
Hauptverfasser:	Apicela Soares, Gisell, Barbosa de Oliveira, Renata, Fernandes de Andrade, Saulo, Alves, Ricardo José, Leomar Zani, Carlos, de Souza-Fagundes, Elaine Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-tumor Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Cancer therapies Carbohydrates Caspase 3 - metabolism Cell Cycle - drug effects Cell death Cell Line, Tumor Cell Proliferation - drug effects cytotoxic activity Cytotoxicity DNA Fragmentation - drug effects DNA, Neoplasm - analysis Drug Screening Assays, Antitumor Enzyme Activation - drug effects Flow Cytometry furan derivatives Humans Investigations Melanoma Morphology
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Zusammenfassung:	In our search for new anticancer therapies, some compounds synthesized in our lab were selected and their potential cytotoxic activity was evaluated in vitro against two cancer cells lines including a solid tumor (UACC-62, melanoma) and a human lymphoma (JURKAT). Compounds showing cytotoxic activity were subjected to an apoptosis assay. Two compounds showed promising results.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules15010012