Editorial: When the prefrontal cortex network goes wrong: the neuroinflammatory impact on behavioral disorders

[...]Shanazz et al. explore susceptibility and resiliency to PTSD in rats, finding that susceptibility to a PTSD-like phenotype is positively correlated with increased levels of IL-6 within the medial prefrontal cortex. Each study highlights important findings that contribute to our current understanding of, and reveal novel insights into, neuroimmune mechanisms that contribute to various disease states. [...]these studies provide evidence for the use of immunomodulatory therapies that may prove beneficial for treating a variety of disease states, including substance use disorders, depression, PTSD and SCIs. Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.