Degradation of ribavirin by Fe2+/PS oxidation technology: performance, mechanism and toxicity control

[Display omitted] •Fe2+/PS system achieves up to 98.70% RBV degradation at optimal conditions.•Identification of SO4-·, ·OH as key active species in RBV degradation.•Degradation follows first-order kinetics in initial 0 – 5 min.•Biotoxicity assessment shows significant toxicity reduction in treated...

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Veröffentlicht in:Arabian journal of chemistry 2024-05, Vol.17 (5), p.105754, Article 105754
Hauptverfasser: Sun, Xiaohui, Li, Wei, Dong, Zijun, Hou, Yunhe, Ning, Yuyang, Wang, Chenyu, Lv, Guo
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Sprache:eng
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Zusammenfassung:[Display omitted] •Fe2+/PS system achieves up to 98.70% RBV degradation at optimal conditions.•Identification of SO4-·, ·OH as key active species in RBV degradation.•Degradation follows first-order kinetics in initial 0 – 5 min.•Biotoxicity assessment shows significant toxicity reduction in treated water.•Study offers insights for post-pandemic pharmaceutical residue management. During the COVID-19 pandemic, the extensive use of ribavirin (RBV) raised concerns about its environmental residues and associated risks, necessitating remedial actions. This study investigates the degradation efficiency, mechanism, and biotoxicity of RBV using ferrous (Fe2+) activated persulfate (PS) advanced oxidation technology (Fe2+/PS oxidation). Experiments conducted under various conditions revealed that at pH = 3, PS concentration of 4 mM, PS/Fe2+ molar ratio of 2:1, and citric acid of 0.5 mM with Fe2+ added twice, the degradation rate of RBV reached 98.70 %. The degradation process of RBV by Fe2+/PS from 0 to 5 mins followed a first-order reaction kinetics model. The presence of halide ions (Cl-, Br-, I-) was found to inhibit the degradation efficiency. The active species involved were identified as SO4-·, ·OH, 1O2, and FeO2+, with SO4-· and ·OH being the most significant. Moreover, the products of ribavirin were determined and their degradation pathways were proposed. Dehydration, deamidation, C-N bond breaking and hydroxylation were the major pathways. Additionally, toxicity assessment showed that Fe2+/PS oxidation reduced the inhibition rate of bioluminescence in Vibrio fischeri from 31.58 % to 3.88 %, effectively controlling RBV toxicity during the reaction. This study provides insights into managing water environmental risks associated with pharmaceutical residues in the post-pandemic era.
ISSN:1878-5352
1878-5379
DOI:10.1016/j.arabjc.2024.105754