Osteogain as a new liquid formulation for emdogain: A review of the literature

Objective: The purpose of this study was to review the scientific evidence regarding the efficacy of Osteogain. Materials and Methods: A literature search for relevant english articles was performed till September, 2017 through PubMed and Google Scholar databases. Results: After screening the titles and abstracts, eight studies were found to be relevant and included in the study while considering the specific criteria. Studies consist of six In Vitro and two Animal studies. Significantly higher amount of total adsorbed amelogenin for Osteogain has been reported by enzyme-linked immunosorbent assay (ELISA). Histologic evaluation showed higher amounts of connective tissue attachment and bone formation for Osteogain. Micro-CT analysis demonstrated that Osteogain induced significant new bone formation. Real-time polymerase chain reaction (PCR) revealed that Osteogain significantly upregulated the expression of the genes involved in osteogenesis and increased alizarin red staining. Conclusions: Most studies indicated promising results about the use of Osteogain in periodontal regeneration. Further investigations are needed to discover the characteristics of this novel liquid enamel matrix derivative (EMD) formulation (Osteogain). Key words: Enamel matrix derivative (EMD), Emdogain, Osteogain.