Advanced oxidation protein products sensitized the transient receptor potential vanilloid 1 via NADPH oxidase 1 and 4 to cause mechanical hyperalgesia

Oxidative stress is a possible pathogenesis of hyperalgesia. Advanced oxidation protein products (AOPPs), a new family of oxidized protein compounds, have been considered as a novel marker of oxidative stress. However, the role of AOPPs in the mechanism of hyperalgesia remains unknown. Our study aim...

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Veröffentlicht in:	Redox biology 2016-12, Vol.10 (C), p.1-11
Hauptverfasser:	Ding, Ruoting, Jiang, Hui, Sun, Baihui, Wu, Xiaoliang, Li, Wei, Zhu, Siyuan, Liao, Congrui, Zhong, Zhaoming, Chen, Jianting
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Advanced oxidation protein products Advanced Oxidation Protein Products - metabolism Animals Calcitonin Gene-Related Peptide - metabolism Cells, Cultured Disease Models, Animal Dorsal root ganglion Freund's Adjuvant - adverse effects Ganglia, Spinal - cytology Ganglia, Spinal - metabolism Gene Expression Regulation - drug effects Hyperalgesia Hyperalgesia - chemically induced Hyperalgesia - metabolism Male NADPH oxidase NADPH Oxidase 1 - metabolism NADPH Oxidase 4 - metabolism Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Research Paper TRPV Cation Channels - metabolism TRPV1
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Zusammenfassung:	Oxidative stress is a possible pathogenesis of hyperalgesia. Advanced oxidation protein products (AOPPs), a new family of oxidized protein compounds, have been considered as a novel marker of oxidative stress. However, the role of AOPPs in the mechanism of hyperalgesia remains unknown. Our study aims to investigate whether AOPPs have an effect on hyperalgesia and the possible underlying mechanisms. To identify the AOPPs involved, we induced hyperalgesia in rats by injecting complete Freund's adjuvant (CFA) in hindpaw. The level of plasma AOPPs in CFA-induced rats was 1.6-fold in comparison with what in normal rats (P
ISSN:	2213-2317 2213-2317
DOI:	10.1016/j.redox.2016.09.004