Ultrasound‐Activated Piezoelectric MoS2 Enhances Sonodynamic for Bacterial Killing

Bacterial infections are a serious public health issue that threatens the lives of patients because of their ability to induce other lethal complications without prompt treatment. Conventional antibiotic therapy can cause bacterial resistance and other adverse effects. It is highly desirable to develop effective and antibiotic‐independent therapeutic strategies to treat various kinds of bacterial infections. Herein, sonodynamic‐enhanced piezoelectric materials MoS2 and Cu2Oheterostructure that responds to exogenous ultrasound (US) and generates reactive oxygen for Staphylococcus aureus elimination are developed. It is shown in the results that the polariton charge induced by piezoelectric MoS2 nanosheets under US irradiation can accelerate the transfer of electric in Cu2O. Furthermore, US irradiation induces valence conversion from Cu(I) to Cu(II), which can accelerate glutathione oxidation significantly and destroy the bacterial antioxidant defense system. Hence, the as‐prepared piezoelectric‐enhanced sonosensitizer possesses a highly effective antibacterial efficacy of 99.85% against S. aureus under US irradiation for 20 min, with good biocompatibility. Herein, effective ultrasonic piezocatalytic therapy is offered through constructing heterogeneous interfaces with ultrasonic piezoelectric response. MoS2/Cu2O (MC) heterojunctions are synthesized by hydrothermal and in situ growth methods. The antibacterial mechanism of MC is studied. MoS2 has piezoelectric properties and can be polarized by ultrasonic excitation, and the polarized charge generated can effectively transfer electrons in Cu2O. Based on the reactive oxygen species generated and depletion of glutathione, the antibacterial rate of MC can reach 99.85%.