Virological and Serological Discordant Profiles in COVID-19 Pneumonia: Two Atypical Clinical Cases

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is primarily diagnosed through viral RNA positivity in nasopharyngeal swabs, and it is associated with the early detection of specific immunoglobulins to SARS-CoV-2 proteins. We describe two moderate coronavirus disease 2019 (COV...

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Veröffentlicht in:	Frontiers in immunology 2020-10, Vol.11, p.580867-580867
Hauptverfasser:	Ranzenigo, Martina, Pastori, Claudia, Siracusano, Gabriel, Pariani, Elena, Uberti-Foppa, Caterina, Lopalco, Lucia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged antibodies Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Clinical Laboratory Techniques Coronavirus Infections - diagnosis Coronavirus Infections - immunology Coronavirus Infections - virology COVID-19 COVID-19 Testing Female Humans Immunology Male Nasal Mucosa - virology neutralizing antibodies Pandemics PCR Pneumonia, Viral - diagnosis Pneumonia, Viral - immunology Pneumonia, Viral - virology Real-Time Polymerase Chain Reaction RNA, Viral - analysis SARS-CoV-2 Serologic Tests viral RNA
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Zusammenfassung:	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is primarily diagnosed through viral RNA positivity in nasopharyngeal swabs, and it is associated with the early detection of specific immunoglobulins to SARS-CoV-2 proteins. We describe two moderate coronavirus disease 2019 (COVID-19) patients with WHO score 4/5 at the time of hospitalization, pneumonia, and oxygen saturation
ISSN:	1664-3224 1664-3224
DOI:	10.3389/fimmu.2020.580867