Do metoclopramide and ondansetrone alter mivacurium-induced neuromuscular blockade? – a randomised trial

We aimed to investigate the effects of metoclopramide and ondansetrone on mivacurium neuromuscular blockade. Seventy five, ASA I-II patients, aged 18-65 and scheduled for elective surgery requiring tracheal intubation were included in the study. The patients received metoclopramide 10mg, ondansetrone 4mg or normal saline 5mL; group M, group O, group NS (n=25), respectively. Before anesthesia study drugs were administered in a volume of 5mL. The level of plasma cholinesterase were obtained before and 5minutes after the administration of study drugs and 5minutes after the administration of mivacurium. Onset time, T25, T75, T25-75, T90 levels were compared with each other and differences between each patients were investigated. After recording T90, the study was terminated and surgery was started. Onset time was significantly shorter in group M, than the other two groups. Onset time in group O was significantly shorter than in group NS. In Group M T25, T75, T90 and recovery indices were significantly greater than in Group NS (p