Development of an innovative minimally invasive primate spinal cord injury model: A case report

Spinal cord injury (SCI) animal models have been widely created and utilized for repair therapy research, but more suitable experimental animals and accurate modeling methodologies are required to achieve the desired results. In this experiment, we constructed an innovative dorsal 1/4 spinal cord transection macaque model that had fewer severe problems, facilitating postoperative care and recovery. In essence, given that monkeys and humans share similar genetics and physiology, the efficacy of this strategy in a nonhuman primate SCI model basically serves as a good basis for its prospective therapeutic use in human SCI. We used an innovative 1/4 transection molding method. After the operation, we examined the effect of the molding by magnetic resonance imaging and proposed a new method of primate spinal cord injury molding.