Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer's Disease

The pathogenesis of Alzheimer's disease (AD) is still unclear, and presently there is no cure for the disease that can be used for its treatment or to stop its progression. Here, we investigated the therapeutic potential of ramalin (isolated from the Antarctic lichen, ), which exhibits various...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2021-10, Vol.26 (21), p.6445
Hauptverfasser:	Kim, Tai Kyoung, Hong, Ju-Mi, Kim, Kyung Hee, Han, Se Jong, Kim, Il-Chan, Oh, Hyuncheol, Yim, Joung Han
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - metabolism Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - therapeutic use antioxidant Antioxidants Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - therapeutic use Aspartic Acid Endopeptidases - antagonists & inhibitors Aspartic Acid Endopeptidases - metabolism Biphenyl Compounds - antagonists & inhibitors Chemical compounds Dementia derivatives Enzymes Fluorine Glutamates - chemical synthesis Glutamates - chemistry Glutamates - therapeutic use Humans Inflammation Molecular Structure Oxidative stress Pathogenesis Pharmacology Physiology Picrates - antagonists & inhibitors Proteins ramalin therapeutic potential β-secratase β-Site APP-cleaving enzyme 1 β-Site APP-cleaving enzymes
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Zusammenfassung:	The pathogenesis of Alzheimer's disease (AD) is still unclear, and presently there is no cure for the disease that can be used for its treatment or to stop its progression. Here, we investigated the therapeutic potential of ramalin (isolated from the Antarctic lichen, ), which exhibits various physiological activities, in AD. Specifically, derivatives were synthesized based on the structure of ramalin, which has a strong antioxidant effect, BACE-1 inhibition activity, and anti-inflammatory effects. Therefore, ramalin and its derivatives exhibit activity against multiple targets associated with AD and can serve as potential therapeutic agents for the disease.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules26216445