Cardiac interventricular septum hemangioma in a colon cancer patient treated with Capecitabine: A case report and review of literature

Key Clinical Message We report a case of a 21‐year‐old male with stage IIIB sigmoid colon adenocarcinoma who experienced atypical chest pain post‐adjuvant chemotherapy with Capecitabine (5‐FU prodrug). Evaluation revealed an unexpectedly detected interventricular septum hemangioma. Due to the vasospasm effect of chemotherapy presenting with semi‐ischemia, conservative management was chosen for atypical presentation. Young male with stage IIIB sigmoid colon adenocarcinoma, treated with XELOX (Oxaliplatin + Capecitabine), developed atypical chest pain, shortness of breath, and tachycardia after Capecitabine. Various cardiac imaging led to hemangioma diagnosis. Capecitabine's arterial vasospasm induction may explain the transient ischemic presentation. Chemotherapy cessation led to asymptomatic hemangioma, requiring periodic follow‐up.