Health-related quality of life and anxiety associated with childhood intermittent exotropia before and after surgical correction

Background Intermittent exotropia (IXT) is the most common form of exotropia in children. In addition to cosmetic effects and loss of stereoscopic function, IXT may negatively impact the psychological well-being of children and their parents. The purpose of this study was to assess the patient-reported outcomes of Chinese children with IXT before and after strabismus surgery. Methods The records of children with IXT who underwent strabismus surgery at the Zhongshan Ophthalmic Center of Sun Yat-sen University, China over the period from January 1, 2016 to December 31, 2018 were prospectively recruited. All children underwent ophthalmic and orthoptic examinations, including the prism and alternate cover test, fusion function by synoptophore, stereoacuity and Newcastle control score. Two patient-reported outcome measures were used: the intermittent Exotropia Questionnaire (IXTQ) to measure disease-specific health-related quality of life (HRQOL) and the Hospital Anxiety and Depression Scale (HADS) to measure anxiety and depression. Patient-reported outcome measurements were made before and after surgery with responses from children and their parents. Results A total of 389 children were eligible for inclusion (47.8% male, 52.2% female, mean + SD age = 8.17 [+ or -] 2.81). Preoperative IXTQ scores in both children (48.21 [+ or -] 26.2) and their parents (44.6 [+ or -] 25.68) were significantly correlated with near stereoacuity (P = 0.029 and P = 0.015, respectively). The angle of deviation at near vision showed a negative linear relationship with visual function (P = 0.026) and psychological (P = 0.019) scores as well as opinions regarding surgery (P = 0.024). HADS scores (anxiety scale score: 11 [+ or -] 2.92, depression scale score: 10.44 [+ or -] 2.9) were also related to near stereoacuity (P < 0.05). After surgery, both children's (74.83 [+ or -] 16.59) and parents' (68.57 [+ or -] 17.06) IXTQ scores significantly improved (p