Neutralizing antibody titers to Omicron six months after vaccination with BNT162b2 in Colombia

The emergence of the Omicron variant has generated concerns about the efficacy of COVID-19 vaccines. We evaluated the serum neutralizing activity of antibodies against the Omicron (lineage BA.1.1) by plaque reduction neutralizing test, as well as its correlation with age and gender, in a Colombian c...

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Veröffentlicht in:	Frontiers in immunology 2022-12, Vol.13, p.1102384-1102384
Hauptverfasser:	Zapata-Cardona, María I, Flórez-Álvarez, Lizdany, Lopera, Tulio J, Chvatal-Medina, Mateo, Zapata-Builes, Wildeman, Diaz, Francisco J, Aguilar-Jimenez, Wbeimar, Taborda, Natalia, Hernandez, Juan C, Rugeles, Maria T
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Neutralizing BNT162 Vaccine Colombia COVID-19 COVID-19 - prevention & control COVID-19 Vaccines Humans Immunology neutralizing antibodies omicron SARS-CoV-2 Vaccination vaccine
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Beschreibung
Zusammenfassung:	The emergence of the Omicron variant has generated concerns about the efficacy of COVID-19 vaccines. We evaluated the serum neutralizing activity of antibodies against the Omicron (lineage BA.1.1) by plaque reduction neutralizing test, as well as its correlation with age and gender, in a Colombian cohort six months after being vaccinated with BNT162b2 (Pfizer/BioNTech). Compared to all other variants analyzed, a significantly lower neutralizing activity (p
ISSN:	1664-3224 1664-3224
DOI:	10.3389/fimmu.2022.1102384