Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda

Artemisinin resistance in Plasmodium falciparum is associated with nonsynonymous mutations in the Kelch 13 (K13) propeller domain. We found that 12.1% (8/66) of clinical P. falciparum isolates from Huye district, Rwanda, exhibited K13 mutations, including R561H, a validated resistance marker. K13 mu...

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Veröffentlicht in:	Emerging infectious diseases 2021-01, Vol.27 (1), p.294-296
Hauptverfasser:	Bergmann, Clara, van Loon, Welmoed, Habarugira, Felix, Tacoli, Costanza, Jäger, Julia C, Savelsberg, Darius, Nshimiyimana, Fabian, Rwamugema, Elias, Mbarushimana, Djibril, Ndoli, Jules, Sendegeya, Augustin, Bayingana, Claude, Mockenhaupt, Frank P
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Antimalarials - pharmacology Antimalarials - therapeutic use Antimicrobial agents antimicrobial resistance artemisinin Dispatch Drug Resistance - genetics Drug resistance in microorganisms Epidemiology Erythrocytes Genetic aspects Genetic polymorphisms Health aspects Humans Increase in Kelch Malaria Malaria, Falciparum - drug therapy Malaria, Falciparum - epidemiology Microscopy Mutation Parasites Patients Plasmodium falciparum Plasmodium falciparum - genetics Polymorphisms in Protozoan Proteins - genetics Rwanda - epidemiology Southern Rwanda Surveillance Tropical diseases
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Zusammenfassung:	Artemisinin resistance in Plasmodium falciparum is associated with nonsynonymous mutations in the Kelch 13 (K13) propeller domain. We found that 12.1% (8/66) of clinical P. falciparum isolates from Huye district, Rwanda, exhibited K13 mutations, including R561H, a validated resistance marker. K13 mutations appear to be increasing in this region.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2701.203527