Giant Epidermal Cyst Unusually Located in Perianal Region

Epidermal cysts are a subset of epithelial inclusion cysts, which are common benign skin lesions. In general, they are usually located on the face, neck, or trunk. However, they may form on any part of the body and occasionally occur in the perianal area. These lesions tend to grow over time and in rare cases can become infected. Total excision is the preferred method of treatment. Definitive diagnosis is made only by histopathological examination. The differential diagnosis of perianal cyst should include hemorrhoids, tailgut cysts, anal canal cysts, retrorectal/presacral cysts, teratomas, and dermoid cysts. Here, we present a rare case of very large perianal epidermal cyst in a male patient who received medical treatment for a diagnosis of hemorrhoids and underwent surgical excision when his symptoms did not improve.