Epigenetic regulation of Epstein–Barr virus: From bench to bedside

Background Epstein–Barr virus (EBV) is a double‐stranded DNA herpesvirus and establishes life‐long infection in 95% of the world's populations. Main body EBV is critically involved in multiple diseases. Aberrant signaling pathways, immune escape, and metabolic reprogramming play essential roles in EBV‐mediated pathogenesis. However, the underlying mechanisms have not yet been fully elucidated. Here we reviewed recent advances on the epigenetic regulation of EBV pathogenesis, which may translate to potential therapeutic strategies in EBV‐associated diseases. Conclusion Growing evidence has suggested that viral infections reconstruct epigenome to modulate gene expression both in the host and the virus levels. EBV acts as an epigenetic driver in carcinogenesis and mainly refers to DNA methylation, RNA methylation, histone modification, chromatin accessibility, and the three‐dimensional (3D) genome structure.