Effect of hypothyroidism on lipid profile in women at Misan City / Iraq

Background : Hypothyroidism is a common endocrine disorder resulting from insufficient production of thyroid hormones, which havesignificant effects on the synthesis, mobilization, and metabolism of lipids. Objective : The present study aimed to measure some hormonaland biochemical parameters in women suffering from hypothyroidism in Misan province. Materials and Methods : This study included 88 women aged 20-35 years. 5-7 ml of blood was drawn, and serum was obtained. Thyroid and lipid profile tests were performed on all women. Results : The values of thyroid stimulating hormone increased statistically significantly (P < 0. 05) in the C (hypothyroidism women) and D (hypothyroidism and infertility women) groups, whereas triiodothyronine and thyroxin results decreased statisticallysignificantly (P < 0. 05) in the C (hypothyroidism women) and D (hypothyroidism and infertility women) groups. Triglycerides and verylow‑density lipoprotein (LDL)‑cholesterol increased statistically significantly (P < 0. 05) in the B (infertility women) and C (hypothyroidism women) groups compared to A (healthy women) and D (hypothyroidism and infertility women) groups, whereas LDL cholesterol (LDL‑Cincreased statistically significantly (P < 0. 05) in C (hypothyroidism women) and D (hypothyroidism and infertility women) groups compared with A (healthy women) and B (infertility women) groups. There were no statistically significant differences (P < 0. 05) in total cholesteroland high‑density lipoprotein‑cholesterol among the study groups. Conclusions: Hypothyroidism causes increasing level of LDL. Indeed, it is a common cause of secondary dyslipidemia.