A Fast and Simple Method for the Determination of TBA in 18F-Labeled Radiopharmaceuticals

A Fast and Simple Method for the Determination of TBA in 18F-Labeled Radiopharmaceuticals

A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various 18F-radiopharmaceuticals is described. The test can be performed in less than five minutes. Iodoplatinate-saturated TLC plates are initially spotted with the 18F-radiopharmaceutical to be tested and...

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Veröffentlicht in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2020-02, Vol.13 (2), p.27
Hauptverfasser: Halvorsen, Nils Erik, Kvernenes, Ole Heine
Format: Artikel
Sprache:eng
Schlagworte:
Antioxidants
Experiments
fdg
fdopa
Iodine
iodoplatinate
Methods
pet
psma
Quality control
radiopharmaceuticals
spot test
tba
Technical Note
tetrabutylammonium
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Zusammenfassung:A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various 18F-radiopharmaceuticals is described. The test can be performed in less than five minutes. Iodoplatinate-saturated TLC plates are initially spotted with the 18F-radiopharmaceutical to be tested and TBA, then with deionized water or hydrogen peroxide (H2O2) solution, depending on if an antioxidant stabilizer is part of the pharmaceutical matrix. A distinct brown spot is visible at TBA concentrations of 50 µg/mL and up.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph13020027