Effects of Sodium Selenite on Formaldehyde Induced Renal Toxicity in Mice

[...]nowadays, each person is either directly or indirectly exposed to formaldehyde.1 Many studies have demonstrated the adverse effects of formaldehyde on the respiratory, cardiovascular and urogenital systems.4-7 It has been shown that formaldehyde leads to degeneration of the glomeruli, dilatation and vacuolization of renal tubules in rat models.8 After exposure to formaldehyde, an increase in serum urea, creatine and malondialdehyde levels is observed while the levels of glutathione peroxidase and superoxide diminished. [...]the number of points hitting the kidney transects were counted Following formula was used to calculate the kidney volume: ... [...]it is recommended for future studies in biochemical analysis such as measurement of antioxidant capacity, markers of inflammation and oxidative stress.