A novel strategy based on the dielectric barrier discharge plasma for rapid elimination of the carryover associated with μPESI-MS/MS system

[Display omitted] •A novel carryover elimination device based on the DBD plasma was developed.•The critical factors affecting the elimination efficiency were washing cycle, gas flow rate, and gas type.•Oxygen was proved indispensable for carryover elimination.•The generation of ROS and RNS were identified as the working mechanism of the device.•The quantitative results indicated the potential of the DBD-WT in fast carryover elimination for μPESI-MS/MS analysis.