Dissemination of Ras V12 -transformed cells requires the mechanosensitive channel Piezo

Dissemination of Ras V12 -transformed cells requires the mechanosensitive channel Piezo

Drosophila tumours can be utilised to study the mechanisms of cell dissemination. Here, the authors use Drosophila midgut to examine the course of Ras V12 -transformed cell dissemination from midgut into circulation, which requires the actions of invasive protrusions and the mechanosensitive channel...

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Veröffentlicht in:Nature communications 2020-07, Vol.11 (1), p.1-13
Hauptverfasser: Jiae Lee, Alejandra J. H. Cabrera, Cecilia M. T. Nguyen, Young V. Kwon
Format: Artikel
Sprache:eng
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Zusammenfassung:Drosophila tumours can be utilised to study the mechanisms of cell dissemination. Here, the authors use Drosophila midgut to examine the course of Ras V12 -transformed cell dissemination from midgut into circulation, which requires the actions of invasive protrusions and the mechanosensitive channel Piezo.
ISSN:2041-1723
DOI:10.1038/s41467-020-17341-y