An Updated Review of Hypertrophic Scarring

Hypertrophic scarring (HTS) is an aberrant form of wound healing that is associated with excessive deposition of extracellular matrix and connective tissue at the site of injury. In this review article, we provide an overview of normal (acute) wound healing phases (hemostasis, inflammation, prolifer...

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Veröffentlicht in:	Cells (Basel, Switzerland) Switzerland), 2023-02, Vol.12 (5), p.678
Hauptverfasser:	Mony, Manjula P, Harmon, Kelly A, Hess, Ryan, Dorafshar, Amir H, Shafikhani, Sasha H
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animal models Animals Blood platelets Blood vessels Care and treatment Cicatrices Cicatrix, Hypertrophic - pathology Collagen Complications and side effects Connective tissue Connective tissues Cytokines Extracellular matrix Extracellular Matrix - pathology Fibroblasts Hemostasis Hyaluronic acid hypertrophic scar Inflammation keloids Models, Animal Neutrophils normal (acute) wound healing Pathogens Prevention Review Reviews Risk factors Scars Skin Skin tumors treatments Tumor necrosis factor-TNF Vascular endothelial growth factor Wound Healing Wounds and injuries
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Beschreibung
Zusammenfassung:	Hypertrophic scarring (HTS) is an aberrant form of wound healing that is associated with excessive deposition of extracellular matrix and connective tissue at the site of injury. In this review article, we provide an overview of normal (acute) wound healing phases (hemostasis, inflammation, proliferation, and remodeling). We next discuss the dysregulated and/or impaired mechanisms in wound healing phases that are associated with HTS development. We next discuss the animal models of HTS and their limitations, and review the current and emerging treatments of HTS.
ISSN:	2073-4409 2073-4409
DOI:	10.3390/cells12050678