Synthesis and Characterization of Hydroxyl-Pinacolone Retinoate

Synthesis and Characterization of Hydroxyl-Pinacolone Retinoate

All-trans retinoic acid (10) was synthesized by β-ionone (5) through knoevenagel condensation, reduction and hydrolysis reaction. Then, hydroxyl-pinacolone retinoate (11) was prepared by the esterification with 1-hydroxy- 3, 3-dimethylbutan-2-ketone. This route not only reduces the synthesis steps b...

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Veröffentlicht in:E3S Web of Conferences 2022, Vol.338, p.1005
Hauptverfasser: Zhang, Hexing, Feng, Baicheng, Jin, Yan
Format: Artikel
Sprache:eng
Schlagworte:
Condensates
Esterification
Ionone
Ketones
NMR
Nuclear magnetic resonance
Retinoic acid
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Zusammenfassung:All-trans retinoic acid (10) was synthesized by β-ionone (5) through knoevenagel condensation, reduction and hydrolysis reaction. Then, hydroxyl-pinacolone retinoate (11) was prepared by the esterification with 1-hydroxy- 3, 3-dimethylbutan-2-ketone. This route not only reduces the synthesis steps but also helps to increase the yield. The structure of the product was characterized by 1 H NMR and 13 C NMR.
ISSN:2267-1242
2555-0403
2267-1242
DOI:10.1051/e3sconf/202233801005