Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal

We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase acti...

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Veröffentlicht in:	Emerging infectious diseases 2018-04, Vol.24 (4), p.741-745
Hauptverfasser:	Isidro, Joana, Santos, Andrea, Nunes, Alexandra, Borges, Vítor, Silva, Catarina, Vieira, Luís, Mendes, Aristides L, Serrano, Mónica, Henriques, Adriano O, Gomes, João Paulo, Oleastro, Mónica
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-Bacterial Agents - pharmacology bacteria Clostridium difficile - classification Clostridium difficile - drug effects Clostridium difficile - genetics Clostridium difficile infection Dispatch Drug Resistance, Bacterial Enterocolitis, Pseudomembranous - epidemiology Enterocolitis, Pseudomembranous - microbiology Genome, Bacterial Health aspects Humans Imipenem Imipenem - pharmacology imipenem resistance Imipenem Resistance in Infection Microbial Sensitivity Tests multidrug resistance Mutation penicillin-binding proteins Phylogeny Portugal - epidemiology Protein binding ribotype 017 Ribotype 017, Portugal Ribotyping Tetracycline Tetracyclines Whole Genome Sequencing
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Zusammenfassung:	We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2404.170095